FGFR1-activated Translation of WNT Pathway Components with Structured 5′ UTRs is Vulnerable to Inhibition of EIF4A-dependent Translation Initiation

Cooperativity between WNT and FGF signaling is well documented in embryonic development and cancer progression, but the molecular mechanisms underlying this crosstalk remain elusive. In this study, we interrogated the dynamics of RNA levels, ribosome occupancy, and protein expression as a function o...

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Vydáno v:Cancer Res
Hlavní autoři: Nguyen, Tuan M., Kabotyanski, Elena B., Dou, Yongchao, Reineke, Lucas C., Zhang, Peng, Zhang, Xiang H.-F., Malovannaya, Anna, Jung, Sung Yun, Mo, Qianxing, Roarty, Kevin P., Chen, Yiwen, Zhang, Bing, Neilson, Joel R., Lloyd, Richard E., Perou, Charles M., Ellis, Matthew J., Rosen, Jeffrey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072612/
https://ncbi.nlm.nih.gov/pubmed/29844125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0631
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