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New tricks for human farnesyltransferase inhibitor: cancer and beyond
Human protein farnesyltransferase (FTase) catalyzes the addition of a C(15)-farnesyl lipid group to the cysteine residue located in the COOH-terminal tetrapeptide motif of a variety of important substrate proteins, including well-known Ras protein superfamily. The farnesylation of Ras protein is req...
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| Publicado no: | Medchemcomm |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072492/ https://ncbi.nlm.nih.gov/pubmed/30108801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00030h |
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