Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

A series of 3-(benzyl-substituted)-imidazo[5,1-d]-1,2,3,5-tetrazines (13) and related derivatives with 3-heteromethyl groups has been synthesised and screened for growth-inhibitory activity in vitro against two pairs of glioma cell lines with temozolomide-sensitive and -resistant phenotypes dependen...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Cousin, David, Hummersone, Marc G., Bradshaw, Tracey D., Zhang, Jihong, Moody, Christopher J., Foreiter, Magdalena B., Summers, Helen S., Lewis, William, Wheelhouse, Richard T., Stevens, Malcolm F. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072467/
https://ncbi.nlm.nih.gov/pubmed/30108945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00554g
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