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Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

Due to emerging resistance there is a steady need for new antimalarial drugs. Here, we report a new class of water soluble, non-toxic compounds, aryl-alkyl-lysines, with promising activity against the ring stage of Plasmodium falciparum. The optimal compound perturbed the plasma membrane potential a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Medchemcomm
Prif Awduron: Ghosh, Chandradhish, Chaubey, Shweta, Tatu, Utpal, Haldar, Jayanta
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071861/
https://ncbi.nlm.nih.gov/pubmed/30108761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00589f
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