Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

IgE is an ancient and conserved immunoglobulin isotype with potent immune function. Nevertheless, the regulation of IgE responses remains enigmatic and evidence for a role of IgE in host defense is limited. Herein we describe that topical exposure to a common environmental DNA-damaging xenobiotic in...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Crawford, Greg, Hayes, Mark David, Castro Seoane, Rocio, Ward, Sophie, Dalessandri, Tim, Lai, Chester, Healy, Eugene, Kipling, David, Proby, Charlotte, Moyes, Colin, Green, Kile, Best, Katie, Haniffa, Muzlifah, Botto, Marina, Dunn-Walters, Deborah, Strid, Jessica
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071860/
https://ncbi.nlm.nih.gov/pubmed/30013146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0161-8
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