Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling

As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), and therefore represents an attractive potential target for treating the various immuno-inflammatory diseases in which...

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Vydáno v:Medchemcomm
Hlavní autoři: Moslin, R., Gardner, D., Santella, J., Zhang, Y., Duncia, J. V., Liu, C., Lin, J., Tokarski, J. S., Strnad, J., Pedicord, D., Chen, J., Blat, Y., Zupa-Fernandez, A., Cheng, L., Sun, H., Chaudhry, C., Huang, C., D'Arienzo, C., Sack, J. S., Muckelbauer, J. K., Chang, C., Tredup, J., Xie, D., Aranibar, N., Burke, J. R., Carter, P. H., Weinstein, D. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2016
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071835/
https://ncbi.nlm.nih.gov/pubmed/30108788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00560h
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