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5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine: a highly potent human cholinesterase inhibitor
The synthesis, cholinesterase inhibition, molecular modelling and ADME properties of novel tacrine–neocryptolepine heterodimers are described. Compound 3 [5-methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine], showing a moderate inhibition of the Aβ(1–42) self-...
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| Udgivet i: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071787/ https://ncbi.nlm.nih.gov/pubmed/30108842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00143f |
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