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Dark chemical matter in public screening assays and derivation of target hypotheses

Compounds that are consistently inactive in many screening assays, so-called dark chemical matter (DCM), have recently experienced increasing attention. One of the reasons is that many DCM compounds may not be fully inert biologically, but may provide interesting leads for obtaining compounds that a...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Jasial, Swarit, Bajorath, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071712/
https://ncbi.nlm.nih.gov/pubmed/30108727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00426e
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