Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data

Characterization of intratumoral heterogeneity is critical to cancer therapy, as the presence of phenotypically diverse cell populations commonly fuels relapse and resistance to treatment. Although genetic variation is a well-studied source of intratumoral heterogeneity, the functional impact of mos...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Fan, Jean, Lee, Hae-Ock, Lee, Soohyun, Ryu, Da-eun, Lee, Semin, Xue, Catherine, Kim, Seok Jin, Kim, Kihyun, Barkas, Nikolaos, Park, Peter J., Park, Woong-Yang, Kharchenko, Peter V.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071640/
https://ncbi.nlm.nih.gov/pubmed/29898899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.228080.117
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