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Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers
Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are normally suppressed in somatic tissues mainly due to DNA methylation and antiviral defense. However, the mechanism to suppress L1s may be disrupted in cancers, thus allowing L1s to act as insertional mutagens and cause genomic r...
Guardat en:
| Publicat a: | Genome Res |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071633/ https://ncbi.nlm.nih.gov/pubmed/29970450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.231837.117 |
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