Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne

Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-rel...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Furue, Masutaka, Fuyuno, Yoko, Mitoma, Chikage, Uchi, Hiroshi, Tsuji, Gaku
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071176/
https://ncbi.nlm.nih.gov/pubmed/30011787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox7070090
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