Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein kinase (AMPK). Herein, we aimed to investigate whether genetic over-express...

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Publicat a:Genes (Basel)
Autors principals: Liñares-Pose, Laura, Rial-Pensado, Eva, Estévez-Salguero, Ánxela, Milbank, Edward, González-García, Ismael, Rodríguez, Claudia, Seoane-Collazo, Patricia, Martinez-Sánchez, Noelia, Nogueiras, Rubén, Prieto, Dolores, Diéguez, Carlos, Contreras, Cristina, López, Miguel
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070933/
https://ncbi.nlm.nih.gov/pubmed/30018241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9070357
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