ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer

BACKGROUND: In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway me...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Cancer
Prif Awduron: Roseweir, Antonia K., Halcrow, Elaine S., Chichilo, Sergey, Powell, Arfon GMT, McMillan, Donald C., Horgan, Paul G., Edwards, Joanne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070918/
https://ncbi.nlm.nih.gov/pubmed/29988110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0174-y
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