Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish

Transcription factor RUNX1 holds an integral role in multiple-lineage haematopoiesis and is implicated as a cofactor in V(D)J rearrangements during lymphocyte development. Runx1 deficiencies resulted in immaturity and reduction of lymphocytes in mice. In this study, we found that runx1(W84X/W84X) mu...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Chi, Yali, Huang, Zhibin, Chen, Qi, Xiong, Xiaojie, Chen, Kemin, Xu, Jin, Zhang, Yiyue, Zhang, Wenqing
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070721/
https://ncbi.nlm.nih.gov/pubmed/30045885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.180043
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