Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc

The quinazoline based drug prazosin (PRZ) is a potent inducer of apoptosis in human cancer cells. We recently reported that PRZ enters cells via endocytosis and induces tubulation of the endolysosomal system. In a proteomics approach aimed at identifying potential membrane proteins with binding affi...

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Publicado en:Biochim Biophys Acta
Main Authors: Fuchs, Robert, Stracke, Anika, Holzmann, Viktoria, Luschin-Ebengreuth, Gerfried, Meier-Allard, Nathalie, Ebner, Nadine, Lassacher, Teresa Maria, Absenger-Novak, Markus, Fröhlich, Eleonore, Schittmayer, Matthias, Crespo, Sara Cano, Palacin, Manuel, Rinner, Beate, Birner-Gruenberger, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070144/
https://ncbi.nlm.nih.gov/pubmed/29909287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2018.06.006
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