Astrocyte-derived Interleukin-33 promotes microglial synapse engulfment and neural circuit development

Neuronal synapse formation and remodeling is essential to central nervous system (CNS) development and is dysfunctional in neurodevelopmental diseases. Innate immune signals regulate tissue remodeling in the periphery, but how this impacts CNS synapses is largely unknown. Here we show that the IL-1...

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Publicado no:Science
Main Authors: Vainchtein, Ilia D., Chin, Gregory, Cho, Frances S., Kelley, Kevin W., Miller, John G., Chien, Elliott C., Liddelow, Shane A., Nguyen, Phi T., Nakao-Inoue, Hiromi, Dorman, Leah C., Akil, Omar, Joshita, Satoru, Barres, Ben A., Paz, Jeanne T., Molofsky, Ari B., Molofsky, Anna V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070131/
https://ncbi.nlm.nih.gov/pubmed/29420261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal3589
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