Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease

BACKGROUND: Metabolism of glutamine by glutaminase 1 (GLS1) plays a key role in tumor cell proliferation via the generation of ATP and intermediates required for macromolecular synthesis. We hypothesized that glutamine metabolism also plays a role in proliferation of autosomal-dominant polycystic ki...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Soomro, Irfana, Sun, Ying, Li, Zhai, Diggs, Lonnette, Hatzivassiliou, Georgia, Thomas, Ajit G, Rais, Rana, Slusher, Barbara S, Somlo, Stefan, Skolnik, Edward Y
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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ORIGINAL ARTICLES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070111/
https://ncbi.nlm.nih.gov/pubmed/29420817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfx349
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