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Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells
BACKGROUND: Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms of chemoresistance in LRCC remain to-date incompletely understood. This study a...
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| Publicado no: | BMC Cancer |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6069886/ https://ncbi.nlm.nih.gov/pubmed/30064387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4690-1 |
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