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Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission

Aged proteins can become hazardous to cellular function, by accumulating molecular damage. This implies that cells should preferentially rely on newly produced ones. We tested this hypothesis in cultured hippocampal neurons, focusing on synaptic transmission. We found that newly synthesized vesicle...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Truckenbrodt, Sven, Viplav, Abhiyan, Jähne, Sebastian, Vogts, Angela, Denker, Annette, Wildhagen, Hanna, Fornasiero, Eugenio F, Rizzoli, Silvio O
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068464/
https://ncbi.nlm.nih.gov/pubmed/29950309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798044
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