Phase I safety and pharmacokinetic study of cipatinib, an original dual tyrosine kinase inhibitor

BACKGROUND: Cipatinib is a novel tyrosine kinase inhibitor against both EGFR and HER2/neu. This phase I trial was conducted to assess the safety, dose‐limiting toxicities (DLTs), and maximum‐tolerated dose of cipatinib in HER2‐positive patients with advanced breast cancer. METHODS: Eligible adults w...

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Detalles Bibliográficos
Publicado en:Thorac Cancer
Main Authors: Wang, Jiayu, Han, Yiqun, Shi, Xiuqing, Li, Qing, Zhang, Pin, Yuan, Peng, Ma, Fei, Luo, Yang, Cai, Ruigang, Fan, Ying, Chen, Shanshan, Li, Qiao, Xu, Binghe
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons Australia, Ltd 2018
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068438/
https://ncbi.nlm.nih.gov/pubmed/29893055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1759-7714.12784
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