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MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B
The heavily transcribed rDNA repeats that give rise to the ribosomal RNA are clustered in a unique chromatin structure, the nucleolus. Due to its highly repetitive nature and transcriptional activity, the nucleolus is considered a hotspot of genomic instability. Breaks in rDNA induce a transient tra...
Uloženo v:
| Vydáno v: | EMBO J |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6068430/ https://ncbi.nlm.nih.gov/pubmed/29789391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798760 |
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