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Dose-related target occupancy and effects on circuitry, behavior, and neuroplasticity of the glycine transporter-1 inhibitor, PF-03463275, in healthy and schizophrenia subjects
BACKGROUND: Glycine transporter-1 (GlyT1) inhibitors may ameliorate cognitive impairments associated with schizophrenia (CIAS). The dose-related occupancy and target engagement of the GlyT1 inhibitor, PF-03463275 were studied to inform optimal dose selection for a clinical trial for CIAS. METHODS: I...
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| Publicado en: | Biol Psychiatry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6068006/ https://ncbi.nlm.nih.gov/pubmed/29499855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.12.019 |
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