Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists

Tight protein-protein interactions (K(d) < 100 nM) that occur over a large binding interface (> 1,000 Å(2)) are highly challenging to disrupt with small molecules. Historically, the design of small molecules to inhibit protein-protein interactions has focused on mimicking the position of inter...

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Vydáno v:ChemMedChem
Hlavní autoři: Xu, David, Bum-Erdene, Khuchtumur, Si, Yubing, Zhou, Donghui, Ghozayel, Mona, Meroueh, Samy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067920/
https://ncbi.nlm.nih.gov/pubmed/28960868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700572
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