Orally Active Opioid μ/δ Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice

(E)-Methyl 2-((2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate (7-hydroxymitragynine), a main active constituent of the traditional herbal medicine Mitragyna speciosa, is an indole alkaloid that is structurally different from m...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Matsumoto, Kenjiro, Narita, Minoru, Muramatsu, Naotaka, Nakayama, Terumi, Misawa, Kaori, Kitajima, Mariko, Tashima, Kimihito, Devi, Lakshmi A., Suzuki, Tsutomu, Takayama, Hiromitsu, Horie, Syunji
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067406/
https://ncbi.nlm.nih.gov/pubmed/24345467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208108
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