Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells

Embryonic stem cells (ESCs) display heterogeneous expression of pluripotency factors such as Nanog when cultured with serum and leukemia inhibitory factor (LIF). In contrast, dual inhibition of the signaling kinases GSK3 and MEK (2i) converts ESC cultures into a state with more uniform and high Nano...

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Pubblicato in:Stem Cell Reports
Autori principali: Hastreiter, Simon, Skylaki, Stavroula, Loeffler, Dirk, Reimann, Andreas, Hilsenbeck, Oliver, Hoppe, Philipp S., Coutu, Daniel L., Kokkaliaris, Konstantinos D., Schwarzfischer, Michael, Anastassiadis, Konstantinos, Theis, Fabian J., Schroeder, Timm
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066909/
https://ncbi.nlm.nih.gov/pubmed/29779897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.019
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