Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells

Embryonic stem cells (ESCs) display heterogeneous expression of pluripotency factors such as Nanog when cultured with serum and leukemia inhibitory factor (LIF). In contrast, dual inhibition of the signaling kinases GSK3 and MEK (2i) converts ESC cultures into a state with more uniform and high Nano...

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Publicado en:Stem Cell Reports
Autores principales: Hastreiter, Simon, Skylaki, Stavroula, Loeffler, Dirk, Reimann, Andreas, Hilsenbeck, Oliver, Hoppe, Philipp S., Coutu, Daniel L., Kokkaliaris, Konstantinos D., Schwarzfischer, Michael, Anastassiadis, Konstantinos, Theis, Fabian J., Schroeder, Timm
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066909/
https://ncbi.nlm.nih.gov/pubmed/29779897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.019
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