Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript

Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicin...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Biol
Autori principali: Ghanem, Louis R., Kromer, Andrew, Silverman, Ian M., Ji, Xinjun, Gazzara, Matthew, Nguyen, Nhu, Aguilar, Gabrielle, Martinelli, Massimo, Barash, Yoseph, Liebhaber, Stephen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066754/
https://ncbi.nlm.nih.gov/pubmed/29866654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00175-18
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