A tRNA-derived small RNA regulates ribosome biogenesis

tRNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments (tRFs)) are an abundant class of small non-coding RNAs whose biological roles are not well defined. We show that inhibition of a specific tsRNA, LeuCAG3′tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-de...

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Publicado en:Nature
Autores principales: Kim, Hak Kyun, Fuchs, Gabriele, Wang, Shengchun, Wei, Wei, Zhang, Yue, Park, Hyesuk, Roy-Chaudhuri, Biswajoy, Li, Pan, Xu, Jianpeng, Chu, Kirk, Zhang, Feijie, Chua, Mei-Sze, So, Samuel, Zhang, Qiangfeng Cliff, Sarnow, Peter, Kay, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066594/
https://ncbi.nlm.nih.gov/pubmed/29186115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25005
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