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Identification of a single aspartate residue critical for both fast and slow calcium-dependent inactivation of the human TRPML1 channel
Transient receptor potential mucolipin subfamily 1 (TRPML1) is a nonselective cation channel mainly located in late endosomes and lysosomes. Mutations of the gene encoding human TRPML1 can cause severe lysosomal diseases. The activity of TRPML1 is regulated by both Ca(2+) and H(+), which are importa...
Kaydedildi:
| Yayımlandı: | J Biol Chem |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6066319/ https://ncbi.nlm.nih.gov/pubmed/29884771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003250 |
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