Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis

We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses...

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Библиографические подробности
Опубликовано в: :Braz J Med Biol Res
Главные авторы: Lu, Yuting, Zhang, Ruili, Wang, Zhenying, Zhou, Shuhua, Song, Yali, Chen, Lamei, Chen, Nan, Liu, Wenmin, Ji, Canan, Wu, Wangli, Zhang, Li
Формат: Artigo
Язык:Inglês
Опубликовано: Associação Brasileira de Divulgação Científica 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065815/
https://ncbi.nlm.nih.gov/pubmed/30043857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1414-431X20187560
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