Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis

We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses...

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Detalhes bibliográficos
Publicado no:Braz J Med Biol Res
Main Authors: Lu, Yuting, Zhang, Ruili, Wang, Zhenying, Zhou, Shuhua, Song, Yali, Chen, Lamei, Chen, Nan, Liu, Wenmin, Ji, Canan, Wu, Wangli, Zhang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Associação Brasileira de Divulgação Científica 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065815/
https://ncbi.nlm.nih.gov/pubmed/30043857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1414-431X20187560
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