Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI

BACKGROUND: Recent clinical data support the utility/superiority of a new AKI biomarker (“NephroCheck”), the arithmetic product of urinary TIMP × IGFBP7 concentrations. However, the pathophysiologic basis for its utility remains ill defined. METHODS: To clarify this issue, CD-1 mice were subjected t...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Johnson, Ali C.M., Zager, Richard A.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2018
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065093/
https://ncbi.nlm.nih.gov/pubmed/29980651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018030265
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