Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice

Although postcapillary pulmonary hypertension (PH) is an important prognostic factor for patients with heart failure (HF), its pathogenesis remains to be fully elucidated. To elucidate the different roles of Rho-kinase isoforms, ROCK1 and ROCK2, in cardiomyocytes in response to chronic pressure over...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sunamura, Shinichiro, Satoh, Kimio, Kurosawa, Ryo, Ohtsuki, Tomohiro, Kikuchi, Nobuhiro, Elias-Al-Mamun, Md., Shimizu, Toru, Ikeda, Shohei, Suzuki, Kota, Satoh, Taijyu, Omura, Junichi, Nogi, Masamichi, Numano, Kazuhiko, Siddique, Mohammad Abdul Hai, Miyata, Satoshi, Miura, Masahito, Shimokawa, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064988/
https://ncbi.nlm.nih.gov/pubmed/29987023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721298115
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