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Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes
The lack of attachment of lipoic acid to its cognate enzyme proteins results in devastating human metabolic disorders. These mitochondrial disorders are evident soon after birth and generally result in early death. The mutations causing specific defects in lipoyl assembly map in three genes, LIAS, L...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6064980/ https://ncbi.nlm.nih.gov/pubmed/29987032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805862115 |
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