Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure‐Overloaded Hearts

BACKGROUND: Insulin resistance in diabetes mellitus has been associated with mitochondrial dysfunction. Defects at the level of mitochondria are also characteristic of heart failure. We assessed changes in cardiac insulin response and mitochondrial function in a model of pressure overload‐induced he...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Main Authors: Nguyen, T. Dung, Schwarzer, Michael, Schrepper, Andrea, Amorim, Paulo A., Blum, Daniel, Hain, Claudia, Faerber, Gloria, Haendeler, Judith, Altschmied, Joachim, Doenst, Torsten
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064925/
https://ncbi.nlm.nih.gov/pubmed/29929988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008865
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