Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: are astrocytes the crossroad?

The development of tolerance to the antinociceptive effect is a main problem associated with the repeated administration of opioids. The progressively higher doses required to relieve pain reduce safety and exacerbate the side effects of classical opioid receptor agonists like morphine. Nociceptin/o...

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Detaylı Bibliyografya
Yayımlandı:Eur J Pharmacol
Asıl Yazarlar: Micheli, Laura, Lucarini, Elena, Corti, Francesca, Ciccocioppo, Roberto, Calò, Girolamo, Rizzi, Anna, Ghelardini, Carla, Mannelli, Lorenzo Di Cesare
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064644/
https://ncbi.nlm.nih.gov/pubmed/29378191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2018.01.039
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