Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of w...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xue, Angli, Wu, Yang, Zhu, Zhihong, Zhang, Futao, Kemper, Kathryn E., Zheng, Zhili, Yengo, Loic, Lloyd-Jones, Luke R., Sidorenko, Julia, Wu, Yeda, McRae, Allan F., Visscher, Peter M., Zeng, Jian, Yang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063971/
https://ncbi.nlm.nih.gov/pubmed/30054458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04951-w
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