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Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity

Cell death by hypoxia followed by reoxygenation (H/R) is responsible for tissue injury in multiple pathological conditions. Recent studies found that epigenetic reprogramming mediated by histone deacetylases (HDACs) is implicated in H/R-induced cell death. However, among 18 different isoforms compri...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ha, Soon-Duck, Solomon, Ori, Akbari, Masoud, Sener, Alp, Kim, Sung Ouk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063935/
https://ncbi.nlm.nih.gov/pubmed/30054507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29463-x
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