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Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells

Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity. We previously demonstrated that cytotoxicity of 2 different metalloenediynes, including (Z)-N,N′-bis[1-pyridyl-2-yl-meth-(E)-ylidene]octa-4-ene-2,6...

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Detalhes bibliográficos
Publicado no:Radiat Res
Main Authors: Keller, Eric J., Porter, Meghan, Garrett, Joy E., Varie, Meredith, Wang, Haiyan, Pollok, Karen E., Turchi, John J., Zaleski, Jeffrey M., Dynlacht, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063758/
https://ncbi.nlm.nih.gov/pubmed/29763378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR15019.1
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