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Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding

Transcription factors normally regulate gene expression through their action at sites where they bind to DNA. However, the balance of activating and repressive functions that a transcription factor can mediate is not completely understood. Here, we showed that the transcription factor PU.1 regulated...

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Publicat a:Immunity
Autors principals: Hosokawa, Hiroyuki, Ungerbäck, Jonas, Wang, Xun, Matsumoto, Masaki, Nakayama, Keiichi I., Cohen, Sarah M., Tanaka, Tomoaki, Rothenberg, Ellen V.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063530/
https://ncbi.nlm.nih.gov/pubmed/29924977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.024
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