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Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data

Prediction of compound toxicity is essential because covering the vast chemical space requiring safety assessment using traditional experimentally-based, resource-intensive techniques is impossible. However, such prediction is nontrivial due to the complex causal relationship between compound struct...

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Detalles Bibliográficos
Publicado en:Toxicol Res (Camb)
Main Authors: Allen, Chad H. G., Koutsoukas, Alexios, Cortés-Ciriano, Isidro, Murrell, Daniel S., Malliavin, Thérèse E., Glen, Robert C., Bender, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062365/
https://ncbi.nlm.nih.gov/pubmed/30090397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5tx00406c
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