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C-type natriuretic peptide analog treatment of craniosynostosis in a Crouzon syndrome mouse model
Activating mutations of fibroblast growth factor receptors (FGFRs) are a major cause of skeletal dysplasias, and thus they are potential targets for pharmaceutical intervention. BMN 111, a C-type natriuretic peptide analog, inhibits FGFR signaling at the level of the RAF1 kinase through natriuretic...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6062116/ https://ncbi.nlm.nih.gov/pubmed/30048539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201492 |
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