A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If uncontrolled, hyperpermeability leads to an impaired barrier, fluid leakage and edema, which can contribute to multi-organ failure and death....

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Amado-Azevedo, Joana, de Menezes, Renee X., van Nieuw Amerongen, Geerten P., van Hinsbergh, Victor W. M., Hordijk, Peter L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062096/
https://ncbi.nlm.nih.gov/pubmed/30048510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201231
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