High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing

DNA polymerase fidelity is affected by both intrinsic properties and environmental conditions. Current strategies for measuring DNA polymerase error rate in vitro are constrained by low error subtype sensitivity, poor scalability, and lack of flexibility in types of sequence contexts that can be tes...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: de Paz, Alexandra M, Cybulski, Thaddeus R, Marblestone, Adam H, Zamft, Bradley M, Church, George M, Boyden, Edward S, Kording, Konrad P, Tyo, Keith E J
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061839/
https://ncbi.nlm.nih.gov/pubmed/29718339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky296
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