The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment

RATIONALE: After stimulation with nitric oxide, soluble guanylate cyclase (sGC) produces cyclic guanosine monophosphate (cGMP), which stimulates an important signalling pathway for long-term potentiation (LTP). By upregulating cGMP, LTP could be stimulated and thereby enhancing memory processes. The...

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Veröffentlicht in:Psychopharmacology (Berl)
Hauptverfasser: Borghans, Laura G. J. M., Sambeth, Anke, Prickaerts, Jos, Ramaekers, Johannes G., Blokland, Arjan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2018
Schlagworte:
Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061766/
https://ncbi.nlm.nih.gov/pubmed/29882087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-4938-0
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