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In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox

There are many mechanisms of neurotoxicity that are initiated by the interaction of chemicals with different neurological targets. Under the U.S. Environmental Protection Agency's ToxCast program, the biological activity of thousands of chemicals was screened in biochemical and cell-based assay...

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Detalhes bibliográficos
Publicado no:Toxicol Res (Camb)
Main Authors: Chushak, Y. G., Shows, H. W., Gearhart, J. M., Pangburn, H. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061186/
https://ncbi.nlm.nih.gov/pubmed/30090592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7tx00268h
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