The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland

Anhydroecgonine methyl ester (AEME), also called methylecgonidine, is a pyrolysis product of crack cocaine that is neurotoxic and potentiates cocaine-induced sensitization. The sensitization induced by drugs of abuse can be influenced by melatonin, a neuroprotective pineal hormone. In the same way,...

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Vydáno v:Toxicol Res (Camb)
Hlavní autoři: Medeiros de Mesquita, Lívia Silva, Garcia, Raphael Caio Tamborelli, Amaral, Fernanda Gaspar, Peres, Rafael, Wood, Simone Miller, Lucena, RodrigoVincenzo de Luca, Frare, Eduardo Osório, Abrahão, Mariana Vieira, Marcourakis, Tania, Cipolla-Neto, José, Afeche, Solange Castro
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2017
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060695/
https://ncbi.nlm.nih.gov/pubmed/30090510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7tx00009j
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