NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder mediated by autoantibodies against the GluN1 subunit of the NMDAR. Patients’ antibodies cause crosslinking and internalization of NMDAR, but the synaptic events leading to depletion of NMDAR are poorly unde...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Ladépêche, Laurent, Planagumà, Jesús, Thakur, Shreyasi, Suárez, Irina, Hara, Makoto, Borbely, Joseph Steven, Sandoval, Angel, Laparra-Cuervo, Lara, Dalmau, Josep, Lakadamyali, Melike
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060408/
https://ncbi.nlm.nih.gov/pubmed/29949761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.096
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