Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study

This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD) was employed to optimize the formulation vari...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Fares, Ahmed R., ElMeshad, Aliaa N., Kassem, Mohamed A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058706/
https://ncbi.nlm.nih.gov/pubmed/29275642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1419512
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