A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

PURPOSE: The RPE cells have a major role in the development of dry age-related macular degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by the Cryba1 gene, a protein known to be important for lysosomal clearance in the RPE, also has a role in epithelial-to-mesenchymal tr...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Ghosh, Sayan, Shang, Peng, Terasaki, Hiroto, Stepicheva, Nadezda, Hose, Stacey, Yazdankhah, Meysam, Weiss, Joseph, Sakamoto, Taiji, Bhutto, Imran A., Xia, Shuli, Zigler, J. Samuel, Kannan, Ram, Qian, Jiang, Handa, James T., Sinha, Debasish
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2018
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Special Issue
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058694/
https://ncbi.nlm.nih.gov/pubmed/30098172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-24132
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