Bone-targeted methotrexate–alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo

Rheumatoid arthritis (RA), a disease that causes joint destruction and bone erosion, is related to osteoclast activity. RA is generally treated with methotrexate (MTX). In this study, a MTX–Alendronate (ALN) conjugate was synthesized and characterized. The conjugate dramatically inhibited osteoclast...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Xie, Zi’ang, Liu, Guanxiong, Tang, Pan, Sun, Xuewu, Chen, Shuai, Qin, An, Zhu, Peizhi, Zhang, Jianfeng, Fan, Shunwu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058523/
https://ncbi.nlm.nih.gov/pubmed/29303005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1422295
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