Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, w...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Pan, Anni, Wang, Zhaoyang, Chen, Binlong, Dai, Wenbing, Zhang, Hua, He, Bing, Wang, Xueqing, Wang, Yiguang, Zhang, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058501/
https://ncbi.nlm.nih.gov/pubmed/29943651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2018.1474971
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